Appell ML, Berg J, Duley J, et al. Nomenclature for alleles of the thiopurine methyltransferase gene. Pharmacogenet Genomics 2013; 23:242. Colombel JF, Ferrari N, Debuysere H, et al. Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy.
thiopurine. (thī″ŏ-pūr′ēn″) [ thio- + purine] Any sulfur-containing purine used as an antimetabolite to treat a variety of auotimmune, inflammatory, and neoplastic diseases. Medical Dictionary, © 2009 Farlex and Partners. Want to thank TFD for its existence?
Konjugation, Unconjugated. Reaktivitet, Human. Värd, Rabbit. Nguyen TV, Vu DH, Nguyen TM, Lachaux A, Boulieu R. Relationship between azathioprine dosage and thiopurine metabolites in pediatric IBD endothelial cells.
(thī″ŏ-pūr′ēn″) [ thio- + purine] Any sulfur-containing purine used as an antimetabolite to treat a variety of auotimmune, inflammatory, and neoplastic diseases. Medical Dictionary, © 2009 Farlex and Partners. Want to thank TFD for its existence? 2018-01-01 Thiopurine therapy is associated with postoperative intra-abdominal septic complications.
The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis), and organ transplant recipients.
350,351 Synthesis, reactions and biological activity of 6-alkyl, 6-arylkyl, 6-aryl, 6-heteroaryl thiopurines, and their 9-substituted derivatives were reviewed. 352 Certain tricyclic derivatives of 6-thiopurine … 2016-08-29 2012-08-29 Thiopurine drugs—6-mercaptopurine (6-MP), 6-thioguanine, and azathioprine—are used in the treatment of leukemia, autoimmune disorders, and solid tumors, as well as in organ transplantations. Among these purine and pyrimidine metabolites, 6-MP is the most prescribed drug for … The thiopurines include azathioprine (a pro-drug for mercaptopurine), mercaptopurine and thioguanine.
Thiopurine drugs are widely used in the treatment of inflammatory and autoimmune diseases, leukaemia and prevention of rejection post organ transplant. Thiopurines are catabolised to inactive metabolites by thiopurine methyl transferase (TPMT), which in effect reduces concentrations of the active metabolite, 6-thioguanine nucleotides (6TGN).
2 The answer may Thiopurine metabolism. Thiopurines are represented by mercaptopurine (MP), azathioprine and thioguanine 20.Both MP and azathioprine are used in paediatrics; these undergo extensive intestinal and hepatic metabolism by a number of enzymes, including hypoxanthine phosphoribosyltransferase (HPRT), TPMT, xanthine oxidase (XO) and inosine monophosphate dehydrogenase (IMPDH). 2012-09-30 Appell ML, Berg J, Duley J, et al. Nomenclature for alleles of the thiopurine methyltransferase gene. Pharmacogenet Genomics 2013; 23:242. Colombel JF, Ferrari N, Debuysere H, et al.
Thiopurine S-methyltransferase.
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Medical Dictionary, © 2009 Farlex and Partners.
The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis), and organ transplant recipients.
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Methotrexate binds to recombinant thiopurine S-methyltransferase and inhibits enzyme activity after high-dose infusions in childhood leukaemia Patricia Wennerstrand, Lars-Göran Mårtensson, Stefan Söderhäll, Malin Lindqvist Appell and Anna Zimdahl Linköping University Post Print N.B.: When citing this work, cite the original article.
Patients with thiopurine S-methyl transferase (TPMT) or nucleotide diphosphatase (NUDT15) deficiency may be at an increased risk of severe and life-threatening myelotoxicity if receiving conventional doses of Azathioprine (see CLINCIAL PHARMACOLOGY). Death associated with pancytopenia has been reported in patients with absent TPMT activity Once thiopurine therapy has been undertaken and an equilibrated drug level is achieved (usually three to six months), literature suggests that the measurement of thiopurine metabolites is warranted in the following situations: 1. Thiopurine Metabolites - 6-Mercaptopurine (Purinethol) and its imidazolyl derivative, Azathioprine (Imuran), are immunosuppressive drugs. 6-Mercaptopurine (6-MP) is indicated for remission induction and maintenance therapy of acute lymphoblastic leukemia (ALL).